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Of these, the molecular enlargement approach was the most effective and enabled us to develop specific inhibitors of CYP707A, UT4 22, abscinazole-E1 25, and abscinazole-E2B (Abz-E2B) 26. Abz-E2B inhibited CYP707A3 effectively in vitro and enhanced drought tolerance in plants through a temporary increase in the endogenous ABA level without growth inhibition.
These results indicated that Abz-E2B is promising, not only as a chemical probe for dissecting the various roles of ABA but also as a plant growth regulator.
Figure 1: Structures of UNI, Abz-E2B and novel CYP707A inhibitors. Full size image Despite the potential value of Abz-E2B for imparting drought-stress resistance to plants, the synthetic yield of 1 is too low for practical uses in agriculture and horticulture.